Describe transaminitis

The major organ in your body is called the liver. It performs 500 functions including most of the chemicals your body needs and making digestive juices to help you break down food. Transaminitis is a term used to describe an elevated level of certain liver enzymes, called transaminases in the blood.

What is the ICD 10 code for elevated transaminase level

Elevation of levels of liver transaminase levels R74.01 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM R74.01 became effective on October 01,2022


1. Production of blood components

2. digestion

3. Cholesterol production

4. Hemoglobin production

5. Detoxification of harmful substances

6. Regulating blood glucose level

7. Regulating blood clotting

8. Defence against disease-causing pathogens

Types of transaminitis

Two of the main types of transaminase in the liver.Alanine transaminase(ALT) and aspartate transaminase(AST).The normal range of values of aspartate transaminase(AST) is about 5 to 40 units and for alanine transaminase(ALT) is about 7 to 56 units. Transaminitis happens when the levels of one or both of these enzymes are higher than normal. This can occur because of certain diseases, medicines, or substance abuse. AST and ALT are both found in low concentrations in blood.

Causes of transaminitis

Injury and inflammation of the liver cells can cause excess production of enzymes that enter your bloodstream. There are a lot of different diseases and conditions that can damage your liver cells. Several blood tests will be performed to determine the amount of liver enzymes in the blood. Some common diseases of transaminitis include alcohol-related liver diseases, non-alcoholic fatty liver diseases, hepatitis, cirrhosis, certain medications, and infectious mononucleosis.

Alcoholic liver disease(ALD)

Alcoholic liver disease occurs when you drink excess amounts of alcohol. Excess alcohol can damage the liver cells. Alcoholic liver disease can progress to steatohepatitis, which is an inflammation of the liver along with fatty liver or cirrhosis. The liver helps break down alcohol, but excessive consumption can damage the liver over time. Heavy drinkers sometimes do not develop ALD, whereas people who drink moderately can develop the condition.

Nonalcoholic fatty liver disease (NAFLD)

Nonalcoholic fatty liver disease happens when there is too much fat stored in the liver of people who don’t drink alcohol. With NAFLD, fat accumulates in your liver, resulting in damage to the liver cells. Typically both AST and ALT are elevated when you have NAFLD.


The most common cause of hepatitis is a virus. These viruses are hepatitis A, B and C. Hepatitis means inflammation of the liver. Hepatitis can cause you to be sick from a few weeks to a few months. As the virus damages the liver cells, liver transaminase leaks into the blood and causes transaminitis. Hepatitis B is primarily spread through bodily spread, including blood and semen. it can lead to chronic liver infections and liver cancer. Hepatitis C is spread through contact with the blood of someone who is infected Unfortunately there is no vaccine for hepatitis C. However an 8 to 12 -course of medicine can cure up to 90 percent of people with chronic hepatitis.

Symptoms of Transaminitis

Loss of appetite and fatigue


Nausea and vomiting


Colored urine looks like dark tea

Abdominal pain and stomach pain or fullness


Light coloured stools

jaundice(the yellow colour of the skin or white colour of eyes


How is Transaminitis diagnosed?

Transaminitis can be diagnosed based on blood work results. Also, routine blood tests are ordered, which helps detect high levels of liver enzymes. It may be ordered in the following situation:

Part of routine blood tests done yearly

If you have symptoms of liver disease

If you are at risk for liver disease

To monitor the treatment of liver disease.

How is transaminitis treated?

Because transaminitis is not a disease, there is no treatment pattern for it. It is a good diagnostic for the success of treatments aimed at reversing the underlying diseases. The treatment for transaminitis will depend on the cause but may include:

Refraining from alcohol use

Loss of weight


Change your diet to avoid red meat, trans fats, high fructose corn syrup and processed carbohydrates

Taking medicines

Monitoring liver functions

Liver transplant

Taking the necessary vaccines for the protection against hepatitis A and B

Asking for alternative medicines if medication is the cause.while there is no vaccine against hepatitis C.

Importance of transaminitis in covid-19 patients

The risk of liver injury in COVID-19 patients is quite evident. Coronavirus disease has been well described in terms of gastrointestinal symptoms. Several studies have been done on the characteristics of patients with transaminitis and those who do not have transaminitis:

Transaminitis cognizing in COVID-19 is important. It will aid clinicians in pathognomy based on the presence and absence of transaminitis at the time of initial presentation.

Transaminase may act as a surrogate marker for disease severity and a predictor of morality.

Transaminitis adjustment

The best and worst food for your liver, is oatmeal, Stay away from fatty foods, broccoli, and coffee, ease up on sugar, green tea, water, almonds, spinach, and blueberries, be moderate with alcohol, herbs, and spices, and limit packaged snack food. Get a checkup regularly so your doctor can keep an eye on how you‘re doing with tests. Follow the commendation treatment for conditions such as high blood pressure and diabetes that can cause liver problems. Check with your doctor about hepatitis vaccines to protect your liver from damage

Writer name

                   Ifrah Khalid


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